United States securities and exchange commission logo January 17, 2023 Vininder Singh Chief Executive Officer BullFrog AI Holdings, Inc. 325 Ellington Blvd., Unit 317 Gaithersburg, MD 20878 Re: BullFrog AI Holdings, Inc. Amendment No. 4 to Registration Statement on Form S-1 Filed January 10, 2023 File No. 333-267951 Dear Vininder Singh: We have reviewed your amended registration statement and have the following comment. In our comment, we may ask you to provide us with information so we may better understand your disclosure. Please respond to this letter by amending your registration statement and providing the requested information. If you do not believe our comment applies to your facts and circumstances or do not believe an amendment is appropriate, please tell us why in your response. After reviewing any amendment to your registration statement and the information you provide in response to this comment, we may have additional comments. Amendment No. 4 to Registration Statement on Form S-1 Financial Statements as of September 30, 2022 (Unaudited) Notes to Financial Statements Note 11 - Shareholder's Equity Warrants, page F-40 1. Please explain to us how the Termination Warrants issued pursuant to the newly disclosed Termination Agreement entered into with ViewTrade Securities Inc. on April 1, 2022, discussed on page 54, are accounted for in your interim financial statements. Vininder Singh FirstName BullFrog AILastNameVininder Singh Holdings, Inc. Comapany January 17,NameBullFrog 2023 AI Holdings, Inc. January Page 2 17, 2023 Page 2 FirstName LastName You may contact Ibolya Ignat at 202-551-3636 or Angela Connell at 202-551-3426 if you have questions regarding comments on the financial statements and related matters. Please contact Tyler Howes at 202-551-3370 or Joe McCann at 202-551-6262 with any other questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Arthur Marcus, Esq.